The evaluation of this correlation may have importance in terms of ruling out the possible apoptotic effect of increased blood glucose level on RGCs, and therefore demonstrating the significant effect of impaired insulin action on retinal neurodegeneration, since both hyperglycemia and deficiency in insulin action have been reported to be involved in apoptotic cell damage of the diabetic mouse retina.37 The gene discussed is INS; the disease is Hyperglycemia.