This link is supported by multiple studies documenting levels of HDL and LDL in cancer patients [2–4], enhanced cholesterol synthesis in cancer cells [5–7], cholesterol accumulation in lipid rafts [8, 9], steroidogenesis in cancer cells [10, 11], over-expression of cholesterol transport receptors: SR-B1 (HDL) and LDL-receptor [12, 13], and more recently, the involvement of the cholesterol metabolite 27HC [14–16]. Here, LDLR is linked to cancer.