In the present study, we clearly show that Pollen Typhae Angustifoliae alcohol extract could increase SR-BI promotor activity, mRNA, and protein expression in LO-2 cell line, indicating that Pollen Typhae Angustifolia is an effective component in Tiaozhi granule, which may play an important role in the treatment of HLP, therefore, processing antiatherosclerotic effect. This evidence concerns the gene SCARB1 and hyperkeratosis lenticularis perstans.