On the other hand, Gabriel et al. [38] studied leucurolysin B (leukocyte-B), which is a P-metalloproteinase class III isolate of B. leucurus in tumor cell lines T98 (p53 mutant malignant glioblastoma), U87 and RT2 (wild-type p53 malignant glioblastoma), MCF7 (breast carcinoma), EAC (Ehrlich ascites carcinoma), and UACC (melanoma) and viewed the chromatin condensation and nuclear fragmentation by DAPI staining, with results similar to ours. Here, TP53 is linked to melanoma.