Another study reported an increase in gastric cancer risk with increased level of some cytokines (IL-1β, IL-2, IL-4, IL-6, IL-8, IL-10, TNF-α, and IFN-γ) and evidenced that, in a population with high gastric cancer incidence and high H. pylori prevalence, increased circulating levels of IL-8 may indicate increased risk of gastric cancer [42]. This evidence concerns the gene IL2 and gastric cancer.