TNF and neoplasm: Indeed, the inflammatory component of a developing neoplasm often includes a very differentiated leukocyte population such as neutrophils, dendritic cells, macrophages, eosinophils, and mast cells, as well as lymphocytes able to produce an assorted array of cytokines, chemotactic cytokines (or chemokines), and soluble mediators of cell killing, such as TNF-α, interleukins, growth factors, and interferons (IFNs) [11, 12].