By multiplexing profiles of cytokines, Gabitass et al. (2011) confirmed this Th2 skewing in pancreatic cancer and extended these observations to esophageal and gastric cancer, demonstrating statistically significant increases in the plasma concentrations of the Th2 cytokines IL-5, IL-6, and IL-10 in patients when compared with controls [44]. This evidence concerns the gene IL10 and familial pancreatic carcinoma.