By comparing ANP-treated mice with vehicle mice, and vascular endothelium–specific GC-A overexpressed with WT mice, in a BLM-induced pulmonary fibrosis model, we showed for the first time that ANP exerts an anti-fibrotic effect on BLM-induced pulmonary fibrosis via vascular endothelial cells. The gene discussed is NPPA; the disease is pulmonary fibrosis.