In different tumor entities including breast cancer, small cell lung cancer, liver cancer, osteosarcoma, prostate cancer and colorectal cancer, the stable RNAi-mediated knockdown of SATB1 has revealed multiple effects on the cellular level, including cell cycle [17, 22, 26], cell proliferation [2, 17, 22, 25, 26, 29], apoptosis [17, 25, 29], epithelial-mesenchymal transition (EMT) [17], invasiveness [2, 16, 22, 25, 26, 29] and/or tumor growth [2, 16, 17, 26, 27, 29]. The gene discussed is SATB1; the disease is colorectal cancer.