The other virus-positive tumor, tumor-076, had a single-copy amplification of MDM4 and single-copy deletions of PTEN and SUFU. In stark contrast to the virus-positive tumors, the virus-negative tumor-050 had single-copy amplifications of EGFR and JUN and single-copy deletions of APC, ATM, BIRC, BRCA1, BRCA2, FANCA, FANCD2, CDKN2A, MLH1, PAX5, PBRM1, RB1, and VHL. RB1 function may be absent in sample-050, as there was a somatic G-to-A transition mutation in the remaining allele at position chr13:49047495. This evidence concerns the gene MDM4 and neoplasm.