To evaluate the possible cumulative role of MG and OH•in the immunopathogenesis of T2DM, 80 serum samples from T2DM patients and 20 normal human subjects were tested for binding to N-IgG, OH•-IgG, MG-IgG and OH•-MG-IgG. The gene discussed is MGAM; the disease is type 2 diabetes mellitus.