Further, IL-1 has been reported to induce cellular responses that cause airway hyper-responsiveness following exposure to ozone.[12,30] The IL-1 pathway was recently reported to be associated with airway inflammation in response to exposure to ozone in individuals with allergic asthma.[18] IL-1α in particular has emerged as a major damage-associated molecular pattern and an inducer of inflammation in a variety of conditions.[31–35] Our results show that administering IL-1α (10 ng/mL) for 24 hours increased the expression of IL-6, IL-8, IL-17, and IFN-γ. This evidence concerns the gene IL1A and allergic asthma.