Allergic conjunctivitis, a common ocular immune disorder, is mediated by pathways similar to those occurring in other allergic diseases, including asthma.[21] The immunopathogenic mechanisms in allergic conjunctivitis involve reactions mediated by immunoglobulin E (IgE) or T-helper 2 cells.[22] The IgE-mediated conjunctival allergic reaction induced by specific conjunctival provocation results in infiltration of predominantly mast cells and eosinophils that produce various inflammatory cytokines.[23,24]. This evidence concerns the gene IGHE and allergic disease.