OVOL2 and posterior polymorphous corneal dystrophy: In this pedigree, the average age at the time of diagnosis of PPCD was 25 years, with a range between 4 and 40 years.[13] Given that the c.-307T>C variant segregates with the affected phenotype in the other 32 affected and unaffected individuals screened, as well as in the 29 individuals in our PPCD1-linked family, the overwhelming likelihood is that these two individuals are in fact affected.[24] This variant has now been demonstrated to segregate with the affected phenotype in three unrelated families that have all been mapped to the PPCD1 locus.