While the majority of affected individuals are thought to be asymptomatic, the percentage of individuals who require corneal transplantation for corneal edema is estimated to be approximately 20%-25%, significantly higher than previously believed.[1] PPCD demonstrates genetic heterogeneity, having been mapped to both chromosome 10 (PPCD3 locus) and 20 (PPCD1 locus). The gene discussed is ZEB1; the disease is posterior polymorphous corneal dystrophy.