We have previously reported the absence of presumed pathogenic variants in the non-coding 1 kb region (containing both the 5’ UTR and promoter) upstream of the ZEB1 translational start site in 31 PPCD probands without a ZEB1 coding region mutation.[8] After six additional PPCD probands without a ZEB1 coding region mutation were identified, we screened the 1 kb upstream of the initiation methionine in these six individuals. This evidence concerns the gene ZEB1 and posterior polymorphous corneal dystrophy.