The 1.8 kb region upstream of the translational start site of OVOL2 was screened in affected and unaffected members of the family with PPCD that was the first to be mapped to the PPCD1 locus on chromosome 20 (Fig 1).[13] Within the promoter region, the c.-307T>C variant was identified in each of the 20 affected family members and was not identified in 12 of the 14 unaffected members who were screened (Fig 1). Here, OVOL2 is linked to posterior polymorphous corneal dystrophy.