APOA5 and hypertriglyceridemia: In association tests between the TG:HDLC ratio and the SNPs, the strongest signal was observed for rs6589566 located downstream of APOA5, an SNP strongly correlated with 3′ UTR rs2266788 (calculated by Haploview version 4.2; r2 = 0.99 and D′ = 1.00 in Han Chinese in Beijing + Japanese population from HapMap 3 release #27) of APOA5. The minor allele of the 3’ UTR SNP reduces has-miR-3021 and has-miR-485-5p binding, resulting in reduced APOA5 expression and hypertriglyceridemia [28,29].