Performance of haplotype-trait association tests indicated that the TCAT haplotype of TLR9 gene (rs5743836, rs187084, rs352139, rs352140) was also associated with HCMV infection, although this association did not reach statistical significance after Bonferroni’s correction (OR 4.23, 95% CI 1.30–13.70, P = 0.018; Pc = 0.005 significance level after Bonferroni’s correction). This evidence concerns the gene TLR9 and cytomegalovirus infection.