The TT genotype of TLR3 rs3775290 was detected in 2/5 children with hepatitis and was associated with a 11-fold increased risk of hepatitis in the unadjusted and adjusted models (OR 11.3, 95% CI 1.34–95.82; P = 0.026), whereas the TT variant of TLR7 rs179008 was associated with an 8-fold higher risk of this symptom (OR 8.33, 95% CI 1.06–65.30; P = 0.044). The gene discussed is TLR3; the disease is hepatitis A virus infection.