In the European Association of Urology guidelines revised in 2016, the panel recommended the use of risk calculators for asymptomatic men with a PSA between 2–10 ng/mL prior to performing a prostate biopsy, because these are useful in helping to determine what the potential risk of PC may be, and thereby reducing the number of unnecessary biopsies [25]. The gene discussed is KLK3; the disease is pachyonychia congenita.