SAMHD1-deficient mice have a dNTP imbalance, with higher intracellular dATP and dGTP concentrations than dTTP and dCTP concentrations [51], and a cellular dNTP imbalance can promote higher rates of mutagenesis in cancer cells, and influence the ability of DNA viruses to infect cells [33, 52–55]. Here, SAMHD1 is linked to cancer.