We used four different cell lines that express HLA-G (choriocarcinoma JEG-3 and melanoma FON) or not (Melanoma M8 and glioma U251MG) to focus on HLA-G 3’UTR haplotypes that are frequently found worldwide, namely UTR-1, UTR-2, UTR-3, UTR-4, UTR-5, UTR- 18 and UTR-7 (Fig 1B). The gene discussed is HLA-G; the disease is melanoma.