To evaluate the role of CCL2 /CCR2 in AML biology, we first determined CCR2 expression in human AML cell lines (THP-1, U-937 and Kasumi-1) and the murine AML cell line (APL) by flow cytometry (FCM), western blot (WB) and real time PCR (qPCR). This evidence concerns the gene CCL2 and acute promyelocytic leukemia.