Upon comparison of 1500 cases of HCC, 1500 healthy controls and individuals with the wild-type homozygous genotype, Zhang H et al.[73]indicated that genetic variants in OCM genes (including MTHFR) may contribute to HCC susceptibility, as those with the heterozygous genotype had a higher HCC risk. This evidence concerns the gene MTHFR and hepatocellular carcinoma.