Importantly, our investigation indicated the possible presence of different mechanisms of miRNA-mediated MTHFR gene silencing;[38] One mechanism involves the following microRNA-mediated mRNA decay in HCC under the condition of FA deficiency: miRNAs trigger deadenylation and subsequent decapping of the MTHFR mRNA target, which leads to the inhibition of mRNA circularization and the promotion of mRNA degradation. Here, MTHFR is linked to hepatocellular carcinoma.