THBS1 and atherosclerosis: The limited evidence in the literature agrees with the model hypothesis that NFAT, with TSP-1 as one of its effector molecules, potently participates in the cellular response to hypoxia/ischemia: inhibition of NFAT is found to suppress atherosclerosis in diabetic mice, while a significant increase in NFAT expression is observed in ischemic rat brain [158, 159].