MDM2 and ischemia: In microarray data that profile mRNA expression in C57BL/6 mouse with or without experimental hindlimb ischemia, TSP-1 and NFAT are among the top 5% most upregulated genes and MDM2 (Mouse double minute 2 homolog, E3 ubiquitin-protein ligase), which promotes p53 degradation, is in the top 5% most downregulated genes in the ischemic group compared to the non-ischemic group; in addition, MYCT1 (Myc target protein 1), whose transcription is directly influenced by Myc availability, is also modestly downregulated in the ischemic group [69, 70].