THBS1 and cancer: Although research has shown that TSP-1 overexpression can effectively reduce tumor metastasis, the position of TSP-1 in the entire network of cancer-related genes is relatively downstream, which might imply that targeting TSP-1 to attack tumor may be less efficacious than targeting the genes (e.g. Myc) that are more central in the network, since cancer is notorious for developing compensatory pathways to resist targeted therapies [145, 146].