Accordingly, the liver genes negatively regulated by NET39 expression in the HT1080 fibroblasts included TDO2 that is regulated by bone morphogenic trancsription factors in liver injury,42TBX3 that has its levels altered at multiple stages in liver differentiation,43ENDOD1 that is associated with metastasis,44 and NNMT that needs to be tightly regulated or else it can yield obesity.45,46. The gene discussed is NNMT; the disease is obesity due to melanocortin 4 receptor deficiency.