For example, cg16292768 (intronic region of the Clusterin gene and upstream of MIR6843), which is hypomethylated in BA11 (P=3.35 × 10−5) of depressed suicide cases compared with controls, is associated with neuritic amyloid plaque burden, an early marker of Alzheimer’s pathology.44 Moreover, cg20434178, located in the promoter region of the autism-associated DLX2 gene,45, 46 is hypermethylated in BA25 (P=5.4 × 10−5) in MDD suicide cases compared with controls. This evidence concerns the gene CLU and major depressive disorder.