Although the function of the PSORS1C3 gene product remains unknown, it is thought to potentially regulate nearby genes (for example, POU5F1 and HLA-C), suggesting a prominent role in immune system regulation.54 Moreover, PSORS1C3 is a known psoriasis susceptibility gene further supporting a role in immune system regulation.54 Of interest, we examined inter-individual variation at the PSORS1C3-associated DMR using a recently developed Blood Brain DNA Methylation Comparison Tool55 (data not shown). Here, POU5F1 is linked to psoriasis.