MMP9 and melanoma: Additionally, solid melanoma grown in left oxter of mice was inhibited after oral intake of 100 and 200 mg/kg of the oil once a day for 28 days, and CD34 expression indicating angiogenesis in melanoma reduced significantly compared with control; melanoma metastatic nodules in lung were also inhibited, as well as MMP-2 and MMP-9 expression in serum [260].