MAPK3 and colonic neoplasm: Taken together, our findings on the differential roles of butyrate in cell proliferation and the activation of ERK1/2, histone hyperacetylation, and c-Myc, p21 protein abundance and intracellular location in cancerous HCT116 and noncancerous NCM460 colon cells may, at least in part, account for the selective potential of butyrate’s anticancer colon cancer action.