CHRNA7 has been associated with several neuropsychiatric and behavioral disorders, such as schizophrenia, bipolar disorder, autism, Alzheimer’s disease, Parkinson’s disease, and 15q13.3 microdeletion and duplication syndromes5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15. Here, CHRNA7 is linked to early-onset autosomal dominant Alzheimer disease.