GRIN2A and ischemia: As showed in Fig. 3A and B, levels of NR2A and p-NR2AS1232 both in cortex and hippocampus increased at 48 h after 2 h ischemia, while the p-NR2AS1232 levels in animals treated with TFP5 were lower than vehicle and Scb groups, which indicated that TFP5 inhibited on phosphorylation of NR2A at Ser1232 site.