Because TDP-43 pathology in motor neurons is a pathological hallmark of ALS31, 32 and because motor neurons exhibiting TDP-43 pathology invariably lack ADAR2 immunoreactivity33, we next examined Nup62 and KPNB1 immunoreactivity in combination with ADAR2 or TDP-43 immunoreactivity in motor neurons of sporadic ALS patients. This evidence concerns the gene TARDBP and amyotrophic lateral sclerosis.