Regarding the first signature network component, hsa-mir-137, hsa-mir-330, hsa-mir-149, hsa-mir-107, hsa-mir-181b were among the miRNAs whose experimentally validated targets (such as CTBP1, CDC42, CDK6, E2F1, VEGFA, AKT1, KAT2B) affect the pathways which play a crucial role in glioblastoma biology. The gene discussed is E2F1; the disease is glioblastoma.