We use two different non-small cell lung cancer (NSCLC) cell lines (H1299, H157) with various perturbations to liver kinase B1 (LKB1) and microtubule affinity regulating kinase 1 (MARK1) pathways23, 25, 26 to demonstrate the discriminatory power of the local alignment vector measure. This evidence concerns the gene MARK1 and non-small cell lung carcinoma.