In approximately 85% of the patients, IgG1 antibodies are directed towards the nicotinic acetylcholine receptors (AChR+)3, while a smaller portion of MG patients possess IgG4 antibodies towards muscle specific tyrosine kinase (MuSK+)4 or low density lipoprotein receptor-related protein 4 (Lrp4)5. The gene discussed is LRP4; the disease is myasthenia gravis.