The MDM2-rs2279744 and MDM2rs937283 variants are located in the MDM2 promoter, which initiates differential transcriptions of MDM2. In this study, the variant T allele was associated with increased risk of SCCOP recurrence, while others reported that individuals with the MDM2 G allele have a decreased risk of oral squamous cell carcinoma and leukemia23, 30. Here, MDM2 is linked to oral cavity squamous cell carcinoma.