Such support is new provided by our co-culture experiments, LPS/IFNγ-treated macrophages (M1-type) could inhibit the growth of U87 glioma cells and MFC breast cancer cells, and CHA was able to affect the interaction of M1 macrophages with glioma cells and induced glioma cells toward an apoptotic-like round shape. The gene discussed is IFNG; the disease is central nervous system cancer.