By virtue of the effect on resting Ca2+[c], the degree of MC activation was potently suppressed, which not only could limit allergic disease, but also might be beneficial to some non-allergic diseases involved MC activation, such as atherosclerosis66, obesity67, 68, diabetes67, 68, chronic obstructive pulmonary disease69, cancer70, postoperative ileus71 and fibromyalgia72, etc. However, our finding, together with the fact that SHL has already been used in the clinic for decades, may offer a suitable novel target for the clinical management of aberrant MC activation in diseases. Here, SERHL is linked to allergic disease.