Wang et al (5) have recently compared the influence of different subcutaneous insulin infusion doses (0.6±0.2 U/kg/day, 1.0±0.2 U/kg/day, and 1.4±0.2 U/kg/day) on BG dynamics of children and adolescents with newly diagnosed T1DM and reported that approximately 90% of patients tolerated the higher insulin doses (1.4±0.2 U/kg/day) for 2 weeks without showing a significant difference regarding severe hypoglycemia rates. This evidence concerns the gene INS and Hypoglycemia.