Sharma et al. evaluated in an animal model with transgenic Ren-2 rats the gene expression of galectin-3 using a complementary DNA array with whole RNA from myocardial biopsies during the progression of heart failure related to renin-dependent hypertension and found an increased myocardial galectin-3 expression in those rats developing heart failure compared to those without [12]. Here, LGALS3 is linked to heart failure.