Indeed, genes involved in glutamate signaling, synaptic plasticity and calcium channel activity were also previously implicated in rare genetic variation studies of schizophrenia.11, 12, 13 Moreover, the genes relevant to the major hypotheses for schizophrenia pathogenesis (for example, DRD2, a validated target for antipsychotic drugs) have also been confirmed in the GWASs,8 adding further evidence for these hypotheses. Here, DRD2 is linked to schizophrenia.