Using the 4C method, Patel et al.131 showed that aberrant TAL1 expression in human T-cell acute lymphoblastic leukemia was mediated by a T-cell acute lymphoblastic leukemia-specific interchromosomal interaction between the TAL1 promoter on chromosome 1 and a regulatory element called TIL16 on chromosome 16.131 Using coined 3C with DNA selection and ligation, a 5C similar technique, Harismendy et al.132 showed that cis-regulatory variants associated with coronary artery disease interacted with IFNA21, located more than 900 kb away. Here, IFNA21 is linked to T-cell acute lymphoblastic leukemia.