We have shown that aberrant ANGPTL2 signaling causes chronic inflammatory diseases, such as obesity, metabolic disease, type 2 diabetes, atherosclerotic disease, and possibly some cancers (Oike & Tabata, 2009; Tabata et al, 2009; Aoi et al, 2011; Endo et al, 2012; Horio et al, 2014). This evidence concerns the gene ANGPTL2 and obesity due to melanocortin 4 receptor deficiency.