Abundant ANGPTL2 expression is reportedly highly correlated with frequency of carcinogenesis and tumor metastasis (Aoi et al, 2011, 2014) in lung cancer (Endo et al, 2012), breast cancer (Masuda et al, 2015), colorectal cancer (Toiyama et al, 2014), and osteosarcoma (Odagiri et al, 2014). This evidence concerns the gene ANGPTL2 and osteosarcoma.