SCCA expression was analyzed by immunohistochemistry on a series of 100 different endoscopy biopsy samples representative of normal esophageal mucosa and each of the phenotypic lesions occurring in the Barrett's oncogenic cascade (N= 20 cases; BM= 20 cases; low-grade intraepithelial neoplasia [LG-IEN]= 20 cases; high-grade intraepithelial neoplasia [HG-IEN]= 20 cases; BAc= 20 cases) (Figure 2A). The gene discussed is SERPINB3; the disease is intraepithelial neoplasia.