Despite the apparent discrepancies concerning the role of UCP2 in carcinogenesis and cancer progression in different types of cells, e.g. UCP2 inhibition of apoptosis in hypoxia, our findings are in accordance with recent reports that UCP2 represses the malignant phenotypes of melanoma, glioma, and pancreatic cancer cells and that UCP2 deficiency mimics the effects of hypoxia in pulmonary hypertension [10, 11, 24, 25]. Here, UCP2 is linked to melanoma.