In our study, we compared the expression of CCL24 in HCC tissues with adjacent normal tissues firstly, the results showed CCL24 was highly expressed in HCC tissues; further analysis of correlation between CCL24 and prognosis of HCC patients reflected overexpression of CCL24 in HCC predicted shorter OS and higher recurrence rates, which implicated CCL24 as a marker for HCC aggressiveness and a predictor for HCC survival. The gene discussed is CCL24; the disease is hepatocellular carcinoma.