Actually, in desensitization of the inflammatory reaction and pathogenesis of asthma, GRK5 and JAK2 produced huge function on promoting CCL24 expression in eosinophil-airway epithelium interaction [21, 22], we tried to investigate both of them expression in HCCs, results revealed they were not associated with CCL24 in HCC (Supplementary Figure S9). Here, GRK5 is linked to hepatocellular carcinoma.