In addition, based on depletion and overexpression experiments in vitro and in vivo, one hypothesis that CCL24 could regulate HCC invasiveness and metastasis was proved; these phenomena naturally urged us to speculate whether CCR3, the downstream of CCL24 changed consistently with CCL24, however, the result seemed CCR3 was irrelevant with CCL24 in HCC in our study. The gene discussed is CCL24; the disease is hepatocellular carcinoma.