Subsequent CCR3, Type 2 helper T cells (Th2 cell) factors, Rho GTPase family, VEGFA, etc. were used to explore their relevance with HCC, qRT-PCR, western blot and Immunohistochemistry were used to explore potential mechanism, ultimate speculation or conclusion was investigated by siRNA validation. This evidence concerns the gene CCR3 and hepatocellular carcinoma.