Miyagaki found that CCR3 was associated with anaplastic large cell lymphoma (ALCL) cells via ERK1/2 activation [16]; CCR3 played a role in the recruitment and retention of CD30+ malignant T cells to the skin in skin-specific cutaneous T-cell lymphoma (CTCL) [17]. This evidence concerns the gene TNFRSF8 and primary cutaneous T-cell non-Hodgkin lymphoma.