Nevertheless it remains unclear how increased levels of MYC-EZH2 are accompanied by low H3K27me3 levels in PCa, but it is reasonable to assume discrepancies by (i) the different experimental procedure followed; (ii) the nature of measurement (i.e., global, vs. promoter-specific levels, etc.); and (iii) the biological material used (cell lines, samples, body fluids, etc.). This evidence concerns the gene MYC and posterior cortical atrophy.