According to the authors, low H3K27me3 levels are regulated, at least in part, to myelocytomatosis oncogene (MYC)overexpression in PCa (known to be a positive regulator of EZH2 expression), although data on histone lysine methyltransferase activity or pEZH2 levels that effect EZH2 affinity for H3 histone were not measured [63,64]. Here, MYC is linked to posterior cortical atrophy.