IFNB1 and infection: Marvin et al. pretreated Caco2 cells with increasing amounts of IFN-β and saw a dose-dependent reduction in new capsid protein synthesis, and, importantly, found that the amount of IFN-β produced during astrovirus infection is sufficient to decrease infectious progeny virion levels, as treatment with an IFN-β neutralizing antibody during infection increased HAstV-1 titers by 2.5 log-units [62].