The same trends were noted in water drinking during the observation periods: nondiabetic control, 5.94 ± 0.281 mL/mouse/day; diabetes without treatment, 19.68 ± 0.454 mL/mouse/day; diabetes with insulin treatment, 4.26 ± 0.090 mL/mouse/day; diabetes with salicylate treatment, 13.35 ± 0.370 mL/mouse/day; diabetes with pyridoxamine treatment, 17.2 ± 0.776 mL/mouse/day. This evidence concerns the gene INS and diabetes mellitus.