For example, while carcinoma antigen 125 (CA125) alone has not been recommended for screening for ovarian carcinoma [29], Lokich et al. could show that the combination of CA125 with HE4, using the Risk of Ovarian Malignancy Algorithm (ROMA), might more accurately define the risk of an epithelial ovarian carcinoma, which would prompt a more aggressive diagnostic workup (e.g., laparoscopy) versus a more conservative management strategy of surveillance in low risk women [30]. Here, WFDC2 is linked to ovarian carcinoma.