Among the proinflammatory cytokines, interleukin 6 (IL-6) and interleukin 1 beta (IL-1β) have a number of functions that are relevant to AD, such as excessive expression of Aβ precursor protein and other plaque-associated proteins, and induction of astrocyte activation and astrocytic overexpression of S100B [13, 14]. This evidence concerns the gene IL1B and Alzheimer disease.