Most of the predicted pathways in our analysis such as Notch, TNF, P53, and TGFβ signaling have been previously known to be involved in the pathogenesis of CKD (16,19), whereas, for some others, such as platelet degranulation pathway, there is not currently direct experimental proof for participation in renal fibrosis. The gene discussed is TGFB1; the disease is chronic kidney disease.