CD274 and chondrosarcoma: Interestingly in our series, we also observed a partial response in one patient with a dedifferentiated chondrosarcoma and a PD-L1 expression that was higher compared to all other tested patients (20% versus less than 5%); additionally, Kostine et al. [15] recently showed that this specific subtype of bone sarcoma expresses PD-L1 in association with immune-infiltrating cells and HLA class I in nearly 50% of cells.