We undertook the first study of association between these CFTR mutations andnon-obstructive azoospermia in Iran.In this case-control study, 100 fertile healthy fathers and 100 non-obstructive azoospermia’smen were recruited from Isfahan Infertility Center (IIC) and Sari Saint Mary’s Infertility Center,between 2008 and 2009. The gene discussed is CFTR; the disease is Azoospermia.