Notably, one study on the progression of pancreatic cancer showed that APN can protect pancreatic beta cells against apoptosis via activation of 5′ AMP-activated protein kinase (AMPK), SIRT1, and peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1α) signaling [28]. The gene discussed is PPARGC1A; the disease is familial pancreatic carcinoma.