Notably, one study on the progression of pancreatic cancer showed that APN can protect pancreatic beta cells against apoptosis via activation of 5′ AMP-activated protein kinase (AMPK), SIRT1, and peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1α) signaling [28]. This evidence concerns the gene PPARGC1A and pancreatic neoplasm.