Furthermore, TBN protected and rescued dopaminergic neurons from 1-methyl-4-phenylpyridinium- (MPP+-) and methyl-4-phenyl-1,2,3,6-tetrahydropyridine- (MPTP-) or 6-hydroxyldopamine- (6-OHDA-) induced damage in vitro and in vivo models of Parkinson's disease (PD) by the reduction of oxidative stress plus increased cellular antioxidative defense capacities [72]. This evidence concerns the gene TAF8 and Parkinson disease.