APOE and Alzheimer disease: In addition, epidemiology evidence indicates that AD and VaD share similar cardiovascular risk factors including apolipoprotein E (APOEε4), hypertension, hypercholesterolemia, obesity, and diabetes [5, 9, 10], although the strength of the association between AD and cardiovascular risk factors could be greatly influenced by the designation of parameters, and further evaluation is needed [11, 12].