Taken together, these findings support that CLA affects the production of eicosanoids either directly or indirectly, enhances PPARγ activation, attenuates the NF-κB pathway, and directly decreases proinflammatory cytokines to have beneficial effects on inflammation, ultimately influencing metabolic syndrome-related conditions, including obesity, IR, and atherosclerosis [132]. Here, NFKB1 is linked to obesity due to melanocortin 4 receptor deficiency.